We understand many patients require the medical benefits of CBD.
Therefore, we provide access to a variety of products with high CBD content.
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Cannabidiol can help you!
Cannabidiol (CBD), a non-psychoactive component of the marijuana plant, has generated significant interest among scientists and physicians in recent years. Cannabidiol is a pleiotropic drug that of which produces many effects through multiple molecular pathways. CBD acts through various receptor-independent channels and by binding with a number of non-cannabinoid receptors and ion channels.
The Science of CBD and FAAH
Unlike psychoactive THC, CBD has little binding affinity to either the CB1 or CB2 cannabinoid receptors. Instead, CBD indirectly stimulates endogenous cannabinoid signaling by suppressing the enzyme fatty acid amide hydroxylase (FAAH) - the enzyme that breaks down anandamide, the first endocannabinoid discovered in the mammalian brain in 1992.
Whereas the cannabinoid molecules found in cannabis are considered "exogenous ligands" to the cannabinoid (CB) receptor family, anandamide is an "endogenous" cannabinoid ligand - meaning it binds to one or more cannabinoid receptors and is found naturally inside the mammalian brain and body. Anandamide favors the CB1 receptor, which is concentrated in the brain and central nervous system. Because FAAH is involved in the metabolic breakdown of anandamide, less FAAH means more anandamide remains present in the body for a longer duration. More anandamide means greater CB1 activation.
CBD enhances endocannabinoid tone by suppressing FAAH.
By inhibiting the enzyme that metabolizes and degrades anandamide, CBD enhances the body's innate protective endocannabinoid response. At the same time, CBD opposes the action of THC at the CB1 receptor, thereby muting the psychoactive effects of THC. CBD also stimulates the release of 2-AG, another endocannabinoid that activates both CB1 and CB2 receptors. CB2 receptors are predominant in the peripheral nervous system and the immune system.
The reduced psychoactivity of CBD-rich cannabis may make it an appealing treatment option for patients seeking anti-inflammatory, anti-pain, anti-anxiety and/or anti-spasm effects without psychoactive symptoms or sleepiness.
Providing access to those severely ill or in need of CBD products is essential to serving others the best we can.